A baby boy battling a rare disease has undergone a life-saving bone marrow transplant after a vital miracle donor was found.

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Reign Miller-Hardy has hemophagocytic lymphohistiocytosis, a condition where his immune system attacks healthy tissues and organs.

The one-year-old was diagnosed in August after being rushed to hospital over fears he had coronavirus.

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A search was launched to find a bone marrow donor, with doctors warning Reign, from Barry, Wales, would die without a transplant.

An initial scan of the worldwide database returned no results, leading to a heartfelt appeal for help and a race against time.

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But Reign’s family has now announced that a match was found in October and the baby is on the road to recovery.

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Reign Miller-Hardy has hemophagocytic lymphohistiocytosis

Great auntie Lisa Evans, 32, said: “Reign had four sessions of stem cell transplantation that lasted over the duration of a week in November.

“The doctors managed to save some of reigns own T cells to put back in along with the donor’s cells.

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“He’s responding brilliantly overall, although he’s having side effects from the chemotherapy and the transplant – but he’s still smiling and staying strong.

“His mum and dad are taking things day by day but are remaining positive. He is still recieving blood and platelets transfusion when required.

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“Reign’s blood cells and neutrophils are increasing daily, which are good signs. It’s showing he’s responding and the transplant is showing success.

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Reign Miller-Hardy desperately needed the life-saving transplant

Reign Miller-Hardy in hospital

“It’s still early days but it’s awesome news. Reign still remains high risk of infection but is allowed outside his ‘bubble’ as his immune system is getting stronger.

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“We are incredibly thankful to the donor and still urge people to sign up if they are eligible for stem cell and blood.”

Brave Reign was diagnosed with the rare disease as ten-month-old after a week of illness. It is though to affect around one in 100,000 children.

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The genetic condition means the immune system attacks healthy tissues and organs including the liver, brain and bone marrow.

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Reign Miller-Hardy was diagnosed with the rare disease in August

His parents Scott Hardy, 28, and Ashleigh Miller, 32, have been with him every step of the way – but only one at at time.

Strict coronavirus restrictions meant the couple had to take it in turns to be at his bedside.

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Lisa, who speaks on behalf of the family, said Reign was first admitted to the University Hospital of Wales, where his condition deteriorated very quickly.

He was then taken for a lumbar puncture and scans where his diagnosis was confirmed.

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Reign started a round of chemotherapy and was put in an induced coma to let his body rest.

The decision was then made to transfer him to the Great North Children’s Hospital in Newcastle, where he is still receiving treatment.

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Lisa added: “We know it’s going to be a long, worrying battle for Reign from this point but we have every faith that our strong boy will continue fighting and get through.”


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